xymp
Bioassay Analysis Software

Xymp® has three integrated modules, which provide a comprehensive solution designed to address challenging problems in cell culture bioassay.

  • The first module drives pipetting robots to implement good plate layouts using statistical designs that incorporate blocks and randomization.
  • The second module provides sophisticated outlier detection, permitting the user to choose whether or not to omit readings that deviate from expectation and may have resulted from procedural errors.
  • The third module implements equivalence testing for similarity via mixed effects data analysis and delivers concise graphical summaries and potency estimates.

In a hand-in-glove fashion, robotically-randomized plate layouts coupled with sophisticated statistical analysis enable Xymp® to attain higher precision from existing bioassays. Higher precision bioassays require fewer replicates and allow higher throughput. Higher throughput equates with faster time to market and increased value.

The Xymp® Value

  • Good experimental designs combined with state-of-the-art statistical analysis lead to high precision
  • High precision bioassay cuts operating costs bringing a value of approximately $350,000 per product during clinical development
  • High precision translates to high throughput, which gets products to market sooner

"A one-day speed advantage typically saves $37,000 in out-of-pocket development costs and nets an additional $1.1 million in daily prescription revenue for an average performing drug." -Tufts Center for the Study of Drug Development

High Precision Bioassay

Our methods provide increased precision that routinely allows companies to cut lab effort in half and in some cases by an order of magnitude. This high precision is attained by applying the best of modern statistical methods for both design and analysis. Use of robotics allows routine randomization and sophisticated plate layouts for cell culture bioassay. Our statistical methods include appropriate selection of transformation, residual–based outlier detection, equivalence–based similarity assessment, and analysis via linear or nonlinear mixed models, shown to have clear advantages over weighted fits.

Benefits of Standardization

Our modular approach routinely delivers precise assays that require minimal development effort and enable standardized methods for validation. Experience with modular designs has shown that dozens of assays can be rapidly adapted to a standardized system with protocol changes isolated to a few modules. Best practices facilitate rapid regulatory approval.

Cost Effective Use of Robotics

Using our bioassay solution, four people and two pipetting robots were able to perform more assays on more samples with higher precision than seven people had been able to perform by hand. By spending less time hand–pipetting, the team had more time to focus on care of cells and designed experiments that refined the performance of the assays. They also were exposed to less risk of repetitive motion injuries.

The Xymp Detail Sheet concisely displays information about assay and sample acceptance criteria in a way that allows fast, easy diagnosis of assay problems. The Detail Sheet enables bench scientists, managers, QA, and regulatory staff to quickly understand an assay and provide an impressive element of presentation to regulators.